Dosing & Administration
Dosing may be titrated according to the following schedule, but titration can be adjusted based on efficacy and tolerability:
titration1
dose
- Twice-daily (AM/PM) dosing with or without a meal1
- Taking Savella with a meal may improve tolerability
- Savella should be tapered and not abruptly discontinued after extended use1

Savella is non-narcotic and is not scheduled.1
No dosage adjustment needed for patients with hepatic impairment or mild renal impairment1
- As with any drug, caution should be exercised in patients with severe hepatic impairment
- Savella should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease
- Savella should be used with caution in patients with moderate renal impairment
- In patients with severe renal impairment, the maintenance dose should be reduced by 50%
- Savella is not recommended for patients with end-stage renal disease